Rus Bio - Mesterolone (Proviron)
In clinical practice Rus Bio Mesterolone is used to treat sexual dysfunction of various kinds, which are most often caused by a low level of endogenous testosterone. It can enhance potency and sexual interest and, in some cases, increase the sperm count. The drug does not stimulate the production of testosterone by the body, it simply replaces its lack. Rus Bio Mesterolone (Proviron) is not an ideal drug for growing muscle mass. It works in the best way in stack with other anabolic steroids such as testosterone. Rus Bio Mesterolone (Proviron) has antiestrogenic activity, i.e. prevents conversion of steroids into estradiol.
Rus Bio Mesterolone (Proviron) History and Overview
Proviron is the trade / brand name for the androgen known as Mesterolone. It is an oral product, and is not considered an anabolic steroid. This is because its anabolic activity is known for being extremely weak – so weak, in fact, that it can be practically considered nonexistent. Proviron was initially developed by Schering in 1934, making it one of the oldest steroids manufactured and marketed for medical use. Mesterolone is so old, in fact, that it shared its inception alongside Methyltestosterone in 1935, and Testosterone Propionate in 1937, which were two of the first anabolic steroids put to use in medicine as well. Of course, Methyltestosterone and Testosterone Propionate are best remembered for all of their glory while Rus Bio Proviron is/was lesser known. This is likely due to the fact that the former two anabolic steroids were demonstrated as being very strong anabolic agents, while the latter was not.
Although Proviron is considered a very old medication, it still stands the test of time as being known as a compound that has impressive effectiveness as a medicine alongside an impressive history of safety and tolerance among patients. Within the medical establishment, Proviron has been utilized as a medication for the treatment of declining well-being in older males due to declining androgen levels, libido dysfunction in males, and infertility.
Its use as a fertility aid is where Proviron was really emphasized in medical literature. This is because while almost all anabolic/androgenic steroids are known to cause temporary infertility, Proviron in normal therapeutic dosages actually barely suppresses endogenous gonadotropins (LH and FSH) when utilized. However, Proviron is poorly misunderstood as a compound that increases LH, which it does not do. Instead, research has demonstrated that Proviron provides the androgenic effects necessary for spermatogenesis in specific areas in the testes.
Schering still manufactures Mesterolone under the name of Proviron across the world today. It has been sold under different brand names as well, including Pluriviron (in Germany by Asche), Vistimon (in Germany by Jenepharm), and Restore (in India, by Brown and Burke). What is interesting, however, is that Proviron was never approved for use on the prescription market in the United States.
Rus Bio Mesterolone (Proviron) Side Effects
Because Rus Bio Mesterolone (Proviron) is a DHT-derivative, it carries with it no risks at any dosage for estrogenic side effects. In fact, as previously mentioned, Rus Bio Mesterolone (Proviron) acts as an anti-estrogen via its activity as an aromatase inhibitor in the body. This can result in the mitigation of estrogenic side effects from other compounds via the reduction of total circulating plasma levels of Estrogen. Research has demonstrated that because of this effect of Rus Bio Mesterolone (Proviron), it has been utilized medically in the treatment of gynecomastia and breast cancers because of its strong androgenic nature combined with its anti-estrogenic capabilities.
Because Rus Bio Mesterolone (Proviron) is primarily an androgen, it does carry with it the risk of androgenic side effects, and they are more pronounced with higher dosages. Rus Bio Mesterolone (Proviron) androgenic side effects include: an increase in oily skin (as a result of increased sebum production/secretion), increased facial hair and bodily hair growth, as well as the increased risk of triggering MPB (Male Pattern Baldness) in those that are genetically sensitive or predisposed to it. Women are also prone to virilization through the use of Rus Bio Mesterolone (Proviron), which is the development of male characteristics in females (i.e. deepening of the voice, facial hair growth, enlargement of the clitoris, etc.). It is also important to note that because Rus Bio Mesterolone (Proviron) is already a derivative of DHT, products such as Finasteride, Proscar, or Dutasteride will do absolutely nothing to reduce Rus Bio Mesterolone (Proviron) potential androgenic side effects.
Because Rus Bio Mesterolone (Proviron) is not C-17 alpha alkylated (it is instead methylated on its first carbon), research has shown that it is not known to produce hepatotoxic effects, and liver problems are extremely unlikely with this compound.
Rus Bio Mesterolone (Proviron) side effects do indeed include negative impacts on the cardiovascular system, however. Studies have shown that 100mg of Rus Bio Mesterolone (Proviron) daily for 6 months has shown very significant negative effects on cholesterol values, both increasing the bad (LDL) cholesterol and decreasing the good (HDL) cholesterol by 65% and 35% respectively.
It is also likely that Rus Bio Mesterolone (Proviron) may have a suppressive effect on endogenous natural Testosterone production (though this is considered to be very weak). Nevertheless, studies have demonstrated that 150mg or less per day of Rus Bio Mesterolone (Proviron) that no significant suppression of Testosterone results. In those same studies, higher dosages (300mg or higher per day) resulted in significant suppression of Testosterone levels.
|Dosage||Men 25-100 mg/day|
|Active half-life||12 hours|